Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hypoxia

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage.

Non-coding RNA·2024

Same author

Editorial: Advances in Cancer Diagnosis and Treatment.

British journal of biomedical science·2024

Same author

The Peer Review Process: Past, Present, and Future.

British journal of biomedical science·2024

Same author

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome.

Translational oncology·2024

Same author

Editorial: The RNA revolution and cancer.

Frontiers in endocrinology·2024

Same author

Assessing the sensitivity and specificity of myositis-specific and associated autoantibodies: a sub-study from the MyoCite cohort.

Rheumatology (Oxford, England)·2024

Same journal

Tracking Synthetic Adhesins on Bacterial Surfaces with Immunofluorescence Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Post-Selection Methods for Analyzing mRNA Display Selections and Optimization of Hits.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

High-Performance Computing in Tandem Mass Spectrometry (MS/MS) Peptide Identification.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Engineering and Adapting Disulfide-Containing Proteins to Enable Intracellular Functionality.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

AI-Driven Protein Research: From Prediction to Design.

Methods in molecular biology (Clifton, N.J.)·2026

Same journal

Methods for the In Vitro Selection of Protein and Peptide Libraries Using mRNA Display.

Methods in molecular biology (Clifton, N.J.)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 24, 2026

Induction and Testing of Hypoxia in Cell Culture

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

Working with Hypoxia.

Elizabeth Bowler¹, Michael R Ladomery²

¹College of Medicine and Health, University of Exeter Medical School, Exeter, UK. e.bowler@exeter.ac.uk.

Methods in Molecular Biology (Clifton, N.J.)

|June 1, 2019

Summary

This summary is machine-generated.

Hypoxia, or oxygen deprivation, is key in diseases like cancer. Understanding how cells adapt to low oxygen environments is crucial for developing new therapies targeting these conditions.

Keywords:

BOLD-MRI Carbonic anhydrase IX Cobalt chloride HIF pathway HIF-1α Hypoxia Hypoxia chamber Hypoxia-activated prodrugs Microelectrode Normoxia Physoxia Pimondiazole Positron emission tomography Reactive oxygen species Tumor hypoxia

More Related Videos

Induction of Hypoxia in Living Frog and Zebrafish Embryos

Induction of Hypoxia in Living Frog and Zebrafish Embryos

Published on: June 26, 2017

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Related Experiment Videos

Last Updated: Jan 24, 2026

Induction and Testing of Hypoxia in Cell Culture

Induction and Testing of Hypoxia in Cell Culture

Published on: August 12, 2011

Induction of Hypoxia in Living Frog and Zebrafish Embryos

Induction of Hypoxia in Living Frog and Zebrafish Embryos

Published on: June 26, 2017

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis

Published on: December 9, 2016

Area of Science:

Physiology
Pathology
Oncology

Background:

Hypoxic environments, characterized by oxygen deprivation, are implicated in numerous diseases, including cardiovascular disease, tissue trauma, stroke, and solid cancers.
While severe oxygen loss leads to cell death, gradual hypoxia allows cells to adapt and potentially promote pathogenic processes like metastatic growth.

Purpose of the Study:

To provide an extensive overview of the mechanisms underlying cellular adaptation to hypoxia.
To discuss current methods for simulating and detecting hypoxic conditions, particularly in the context of tumors.
To review existing and experimental therapies targeting hypoxic cells.

Main Methods:

Literature review and synthesis of existing research on hypoxia.
Description of techniques used to simulate and detect hypoxic environments.
Analysis of therapeutic strategies targeting hypoxic cells.

Main Results:

Hypoxia plays a significant role in various disease pathways, influencing cell survival and adaptation.
Current methodologies for simulating and detecting hypoxia are essential for research and clinical applications.
Therapeutic interventions targeting hypoxic cells show promise in managing diseases characterized by low oxygen.

Conclusions:

Understanding the multifaceted role of hypoxia in disease pathogenesis is fundamentally important.
Effective simulation and detection of hypoxia are critical for advancing research and treatment.
Targeting hypoxic cells represents a promising avenue for novel therapeutic strategies in various diseases.