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Updated: Jan 24, 2026

Well-aligned Vertically Oriented ZnO Nanorod Arrays and their Application in Inverted Small Molecule Solar Cells
Published on: April 25, 2018
Bioadaptive nanorod array topography of hydroxyapatite and TiO2 on Ti substrate to preosteoblast cell behaviors
Shumin Pang1, Manman Sun1, Zhiqiang Huang1
1Department of Materials Science and Engineering, Jinan University, Guangzhou, China.
Abstract:
Bioadaptive nanostructure coatings of hydroxyapatite (HAP) and TiO2 on titanium (Ti) implants are essential for biomaterial-tissue osteointegration. However, there is no specific report, so far, that focuses on the different influences of the two bioadaptive coatings on preosteoblast behaviors. Herein, adhesion, proliferation, and osteogenic potential of preosteoblast on HAP and TiO2 coatings with nanorod array topography were studied. XRD, TEM, and SAED analysis indicated that rod-like HAP nanoarray and anatase TiO2 nanoarray coatings were fabricated successfully, and there was insignificant difference in roughness and fibronectin adsorption of the two coatings. Adhesion and proliferation of MC3T3-E1 cells on the two coatings were of no significant difference, besides a larger projected area of the cells on HAP coating. MC3T3-E1 cells cultured on the HAP coating displayed significantly higher expression of runt-related transcription factor-2 (Runx2), osteocalcin (OCN) and collagen type-1 (Col I) after culture for 21 days compared with those on TiO2 coating, except alkaline phosphatase (ALP). This study provides beneficial suggestion for intelligent selection of biocoatings.
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