Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gravity-induced hyperventilation is caused by a reduced brain perfusion.

R Arieli, L E Farhi

    Respiration Physiology
    |August 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pulmonary oxygen toxicity index during linear change in PO<sub>2</sub>: HBO treatment tables and dive planning.

    Respiratory physiology & neurobiology·2023
    Same author

    The pulmonary oxygen toxicity index.

    Respiratory physiology & neurobiology·2023
    Same author

    Dipalmitoylphosphatidylcholine in the heart of mice with lupus might support the hypothesis of dual causes of autoimmune diseases.

    Respiratory physiology & neurobiology·2022
    Same author

    Ex vivo bubble production from ovine large blood vessels: size on detachment and evidence of "active spots".

    Respiratory physiology & neurobiology·2014
    Same author

    Evolution of bubbles from gas micronuclei formed on the luminal aspect of ovine large blood vessels.

    Respiratory physiology & neurobiology·2013
    Same author

    Dynamics of gas micronuclei formed on a flat hydrophobic surface, the predecessors of decompression bubbles.

    Respiratory physiology & neurobiology·2012

    Increased gravity may cause hyperventilation by reducing brain blood flow. A new mathematical model explains this effect on the respiratory center, aligning with experimental data.

    Area of Science:

    • Physiology
    • Aerospace Medicine
    • Mathematical Modeling

    Background:

    • Hyperventilation during increased gravity (Gz) is a known phenomenon.
    • A proposed mechanism involves decreased brain perfusion affecting the respiratory center (RC).

    Purpose of the Study:

    • To develop a mathematical model predicting the impact of Gz on RC blood flow and CO2 regulation.
    • To validate the model using existing physiological data.

    Main Methods:

    • Utilized the CO2 balance equation for the respiratory center.
    • Incorporated a novel equation relating RC blood flow (QRC) to Gz and PaCO2: QRC = [1 - a(Gz - 1)](b X PRCCO2 + c).
    • Calculated coefficients a, b, and c from literature data.

    Main Results:

    Related Experiment Videos

    • The model demonstrates that RC blood flow is significantly affected by +Gz primarily at high PaCO2 levels.
    • The model accurately predicts oxygen pressure in the RC.
    • Calculated values show good agreement with experimentally measured jugular vein PO2.

    Conclusions:

    • The developed mathematical model provides a quantitative explanation for Gz-induced hyperventilation.
    • The model highlights the critical role of PaCO2 in modulating the effects of Gz on cerebral perfusion and respiratory control.