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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
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Autoimmune hepatitis and IgG4-related disease
Kosuke Minaga1, Tomohiro Watanabe2, Hobyung Chung3
1Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.
World Journal of Gastroenterology
|June 1, 2019
Summary
Immunoglobulin G4-related disease (IgG4-RD) can affect the liver, leading to a subtype of autoimmune hepatitis (IgG4-associated AIH). This review discusses the clinicopathological features of IgG4-associated AIH.
Area of Science:
- Immunology
- Gastroenterology
- Pathology
Background:
- Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory condition.
- Hepatic involvement in IgG4-RD is not well-defined.
- A subtype of autoimmune hepatitis (AIH), termed IgG4-associated AIH (IgG4-AIH), has been recently identified.
Purpose of the Study:
- To review and discuss the clinicopathological features of IgG4-associated AIH.
- To clarify the diagnostic criteria and potential classification of IgG4-AIH.
- To highlight the relationship between IgG4-AIH and IgG4-RD.
Main Methods:
- Literature review of studies identifying IgG4-associated AIH.
- Analysis of diagnostic criteria used in reported cases.
- Synthesis of clinicopathological findings from existing literature.
Main Results:
- IgG4-AIH is diagnosed by IgG4-positive plasmacyte infiltration in the liver of AIH patients.
- Diagnostic criteria vary, with some studies relying solely on liver histology and others including elevated serum IgG4.
- IgG4-AIH diagnosed with elevated serum IgG4 may represent hepatic IgG4-RD, while others may be an AIH subtype.
Conclusions:
- IgG4-associated AIH presents distinct clinicopathological features.
- Further research is needed to establish definitive diagnostic criteria and classification.
- Understanding IgG4-AIH is crucial for managing liver manifestations of IgG4-RD.
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