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Transthoracic Echocardiographic Examination in the Rabbit Model
Published on: June 1, 2019
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ECHOCARDIOGRAPHIC MYOCARDIAL CHANGES IN ACROMEGALY: A CROSS-SECTIONAL ANALYSIS IN A TERTIARY CENTER IN BULGARIA.
E Natchev1, A Kundurdjiev2, N Zlatareva3
1Medical University of Sofia, Faculty of Medicine, Department of Endocrinology, Sofia, Bulgaria.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Acromegaly patients show impaired heart function, particularly diastolic dysfunction in the left ventricle. Echocardiographic markers revealed abnormalities not directly correlated with disease duration, growth hormone, or IGF-1 levels.
Area of Science:
- Cardiology
- Endocrinology
- Medical Imaging
Background:
- Cardiomyopathy is a frequent cardiovascular complication in acromegaly.
- Acromegaly can lead to significant cardiac alterations affecting ventricular function.
Purpose of the Study:
- To compare echocardiographic markers in acromegaly patients versus controls.
- To investigate correlations between cardiac markers and disease duration, activity, GH, and IGF-1 levels.
Main Methods:
- Cross-sectional case-control study (2008-2012) with 146 acromegaly patients and 83 controls.
- Echocardiography (1D, 2D, color, pulse Doppler) performed on all participants.
- Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels measured.
Main Results:
- Increased left ventricular mass and wall thickness observed, though not always statistically significant.
- Diastolic dysfunction markers (increased deceleration time, isovolumetric relaxation) were age-dependent, not correlated with GH or IGF-1.
- Systolic dysfunction and right ventricular involvement were more prevalent in acromegaly patients.
Conclusions:
- Functional impairments in both ventricles are present in acromegaly.
- Left ventricular diastolic dysfunction predominates, influenced by age rather than disease-specific hormonal factors.
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