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Related Experiment Video

Updated: Jan 24, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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EFFECTS OF EXERCISE ON MIR-29 AND IGF-1 EXPRESSION AND LIPID PROFILE IN THE HEART OF OVARIECTOMIZED RAT.

P Habibi1, A Alihemmatti2, M Alipour3

  • 1Tabriz University of Medical Sciences, Department of Physiology, Islamic Republic of Iran.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed
Summary

Swimming exercise improves heart health in ovariectomized rats by increasing miR-29 and IGF-1 expression. This intervention offers a protective effect against cardiac fibrosis, suggesting exercise benefits post-menopause.

Keywords:
IGF-1OvariectomyheartmiR-29swimming training

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Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Molecular Biology

Background:

  • Menopause is associated with increased cardiovascular disease risk in women.
  • Estrogen deficiency can negatively impact cardiac structure and function.
  • Ovariectomy in rats serves as a model for post-menopausal changes.

Purpose of the Study:

  • To investigate the impact of swimming training on cardiac histology.
  • To assess changes in miR-29 and Insulin-like Growth Factor 1 (IGF-1) expression in the heart.
  • To evaluate the protective effects of exercise in an ovariectomized rat model.

Main Methods:

  • Ovariectomized (OVX) and sham-operated female Wistar rats were used.
  • Groups included sedentary controls (OVX) and those undergoing 8 weeks of swimming exercise (OVX.E).
  • Cardiac histology, lipid profiles, IGF-1 mRNA, and miR-29 expression were analyzed.

Main Results:

  • Ovariectomy significantly reduced cardiac miR-29 and IGF-1 expression compared to sham controls.
  • Swimming exercise training upregulated miR-29 and IGF-1 expression in OVX rats.
  • Exercise improved cardiac histology and lipid profiles in the trained OVX group.

Conclusions:

  • Estrogen deficiency may promote cardiac fibrosis via dysregulation of miR-29 and IGF-1.
  • Exercise demonstrates a protective effect on the heart against fibrosis in ovariectomized rats.
  • Exercise may have preventive value in enhancing cardiac function after menopause.