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RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS
C I Bondor1, A R Potra2, C C Rusu2
1"Iuliu Hatieganu" University of Medicine and Pharmacy, Medical Informatics and Biostatistics, Cluj-Napoca, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
In type 2 diabetes, higher oxidative stress markers correlate with lower urinary Angiotensin converting enzyme 2 (uACE2). This suggests uACE2 may indicate kidney health in T2DM patients with oxidative stress.
Area of Science:
- Nephrology
- Endocrinology
- Biochemistry
Background:
- Angiotensin converting enzyme 2 (ACE2) plays a protective role in the kidney by counteracting angiotensin II-induced oxidative stress.
- Oxidative stress is a known complication in type 2 diabetes mellitus (T2DM).
Purpose of the Study:
- To investigate the association between oxidative stress markers and urinary ACE2 (uACE2) levels in patients with T2DM.
- To understand the role of uACE2 in the context of oxidative stress in T2DM.
Main Methods:
- An observational transversal study included T2DM patients with normal or microalbuminuria.
- Assessed plasma malondialdehyde (MDA) as a prooxidant marker, and erythrocyte superoxide dismutase (SOD) and catalase (CAT) as antioxidant markers.
- Measured urinary ACE2 (uACE2) using ELISA.
Main Results:
- Plasma MDA showed a negative correlation with SOD, CAT, and uACE2.
- Higher MDA levels were associated with lower uACE2 levels.
- uACE2 was identified as the sole predictor for MDA levels in multivariate logistic regression.
Conclusions:
- Increased prooxidant capacity, indicated by higher MDA, is linked to reduced uACE2 levels in T2DM patients.
- These findings highlight a potential relationship between oxidative stress and kidney protection via ACE2 in T2DM.
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