Related Experiment Video
Updated: Jan 24, 2026
09:48
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
3.5K
VITAMIN DEFICIENCY AND INSULIN RESISTANCE IN NONDIABETIC OBESE PATIENTS
O Cigerli1, H Parildar1, A Dogruk Unal2
1Baskent University Istanbul Hospital - Department of Family Medicine - Istanbul, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Obese individuals often have low vitamin D, B12, and folic acid levels, which are linked to insulin resistance. Poor vitamin status in obesity may contribute to metabolic health issues.
Area of Science:
- Nutrition Science
- Endocrinology
- Metabolic Health
Background:
- Obesity is frequently associated with nutritional deficiencies despite high caloric intake.
- Understanding micronutrient status in obese populations is crucial for metabolic health management.
Purpose of the Study:
- To investigate the relationship between vitamin D, B12, and folic acid levels, dietary intake, and insulin resistance in obese individuals.
- To assess the prevalence of vitamin deficiencies in a non-diabetic obese cohort.
Main Methods:
- A case-control study involving 304 obese subjects and 150 normal-weight controls.
- Detailed dietary intake assessment and measurement of serum vitamin D, B12, and folic acid levels.
- Evaluation of insulin resistance using HOMA-IR.
Main Results:
- Obese patients exhibited significantly lower vitamin D, B12, and folic acid levels compared to controls.
- High prevalence of vitamin D (69.7%), B12 (13.5%), and folic acid (14.2%) deficiencies observed in obese subjects.
- Lower vitamin levels and poor vitamin D and B12 status were associated with increased insulin resistance (HOMA-IR).
- Dietary intake of vitamin D and folic acid was inadequate in all obese patients.
Conclusions:
- Nondiabetic obese individuals frequently present with low levels of vitamin D, B12, and folic acid.
- Poor vitamin D and B12 status are significantly associated with insulin resistance in this population.
- These findings highlight the importance of assessing and addressing vitamin deficiencies in obese patients to manage metabolic complications.
Related Concept Videos
01:21Drug Dosing: Obese Patients
238
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
238
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
260
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
260
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
175
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
175
01:30Vitamins
2.3K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
01:24Obesity
1.2K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
01:05Insulin Secretory Vesicles
6.4K
Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
6.4K