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ORBITAL PSEUDOTUMOR CAN MIMIC GRAVES' OPHTHALMOPATHY
M Stanciu1, F L Popa1, I G Totoian1
1"Lucian Blaga" University of Sibiu, Faculty of Medicine, Dept of Endocrinology, Sibiu, Romania.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Orbital pseudotumor (OP) is a rare inflammatory condition mimicking Graves' ophthalmopathy. Orbital MRI and biopsy are crucial for diagnosing OP, especially when TRAb tests are negative in euthyroid patients with proptosis.
Area of Science:
- Ophthalmology
- Inflammatory Disorders
- Diagnostic Imaging
Background:
- Orbital pseudotumor (OP) is a benign orbital inflammatory condition characterized by lymphoid infiltrates and fibrosis.
- Graves' ophthalmopathy (GO) is a common cause of proptosis, presenting unilaterally or bilaterally.
Observation:
- A patient presented with unilateral proptosis initially misdiagnosed as euthyroid Graves' disease.
- Magnetic Resonance Imaging (MRI) revealed inflammation of orbital fat, muscles, and the lacrimal gland.
- Biopsy confirmed orbital pseudotumor, refuting the initial Graves' disease diagnosis.
Findings:
- Orbital pseudotumor can clinically and radiographically mimic other inflammatory orbital diseases, particularly Graves' ophthalmopathy.
- Orbital MRI is a critical diagnostic tool for differentiating these conditions.
- A negative Thyroid Receptor Antibody (TRAb) test in euthyroid patients with proptosis warrants further investigation for OP.
Implications:
- Accurate diagnosis of orbital pseudotumor is essential for appropriate treatment and management.
- Orbital MRI plays a pivotal role in the diagnostic workup of proptosis.
- Considering orbital pseudotumor in the differential diagnosis of euthyroid proptosis with negative TRAb is clinically significant.
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