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NEED OF IRON SUPPLEMENTATION IN GESTATIONAL DIABETES MELLITUS.

A Yadav1, V Saini2, M Kataria2

  • 1Lady Hardinge Medical College, Department of Biochemistry, New Delhi, India.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed
Summary

High serum ferritin levels in pregnant Indian women are linked to gestational diabetes mellitus (GDM). This finding may inform iron supplementation strategies during pregnancy.

Keywords:
ferritingestational diabetes mellitus

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Area of Science:

  • Reproductive Medicine
  • Endocrinology
  • Nutritional Science

Background:

  • Gestational diabetes mellitus (GDM) poses risks to both mother and fetus.
  • Iron supplementation is common in Indian pregnancies, but its relation to GDM is unclear.
  • Serum ferritin levels may indicate iron status and inflammation during pregnancy.

Purpose of the Study:

  • To investigate the association between serum ferritin levels and GDM in an Indian population.
  • To explore the correlation between ferritin and blood glucose in GDM patients.

Main Methods:

  • A case-control study involving 90 pregnant women (30 GDM, 60 controls) in New Delhi.
  • Serum ferritin was quantified using ELISA.
  • Correlation analysis between ferritin and blood glucose was performed for GDM cases.

Main Results:

  • Serum ferritin levels were significantly higher in women with GDM compared to controls (p=0.008).
  • A non-significant negative correlation was observed between ferritin and blood glucose levels (r=-0.039, p=0.794).

Conclusions:

  • Elevated serum ferritin may be associated with increased GDM risk in pregnant Indian women.
  • Pregnancy-associated inflammation might contribute to higher ferritin levels.
  • Further large-scale studies are needed to confirm these findings and their clinical implications.