Related Experiment Video
Updated: Jan 24, 2026
12:48
Induction of Endothelial Differentiation in Cardiac Progenitor Cells Under Low Serum Conditions
Published on: January 7, 2019
6.8K
SERUM OMENTIN-1 LEVELS AND ENDOTHELIAL DYSFUNCTION IN OBESITY
A R Çimen1, E T Cerit1, O T Iyidir1
1Gazi University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Serum omentin-1 levels are lower in obese patients, correlating with poorer endothelial function. These findings suggest omentin-1 may serve as an early indicator of endothelial dysfunction in obesity.
Area of Science:
- Endocrinology
- Cardiovascular Research
- Metabolic Syndrome
Background:
- Obesity is associated with increased cardiovascular risk.
- Endothelial dysfunction is an early predictor of atherosclerosis.
- Omentin-1 is an adipokine with potential protective roles.
Purpose of the Study:
- To investigate the association between serum omentin-1 levels and endothelial dysfunction in obese individuals.
- To explore the relationship between omentin-1 and metabolic parameters in obesity.
Main Methods:
- Cross-sectional study comparing 50 obese patients with 45 healthy controls.
- Measurements included oral glucose tolerance test, lipid profile, uric acid, HOMA-IR, serum omentin-1, and flow-mediated dilation (FMD).
- Body composition analyzed using bioelectrical impedance.
Main Results:
- Obese patients exhibited significantly lower serum omentin-1 levels and reduced FMD compared to controls.
- Serum omentin-1 showed a positive correlation with FMD (r=0.359, p<0.001).
- Omentin-1 levels were negatively correlated with BMI, waist circumference, body fat percentage, visceral fat, fasting insulin, and HOMA-IR.
Conclusions:
- Reduced serum omentin-1 levels and impaired FMD may indicate early endothelial dysfunction in obesity.
- Omentin-1 warrants further investigation as a potential biomarker for cardiovascular risk in obese populations.
More Related Videos
Related Concept Videos
01:24Obesity
1.2K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
01:21Drug Dosing: Obese Patients
238
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
238
01:19High-Level and Low-Level Awareness
632
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
632
01:29Leveling Effect
1.4K
In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
1.4K
01:09Levels of Organization
139.2K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
139.2K
01:18Fermi Level
1.7K
The Fermi-Dirac function is represented by an S-shaped curve indicating the probability of an energy state being occupied by an electron at a given temperature. The Fermi level is the energy level at which there is a fifty percent chance of finding an electron, and it is positioned between the lower-energy valence band and the higher-energy conduction band.
At absolute zero temperature, electrons fill all energy states up to the Fermi level, leaving upper states empty. As the temperature rises,...
At absolute zero temperature, electrons fill all energy states up to the Fermi level, leaving upper states empty. As the temperature rises,...
1.7K