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MOLECULAR PATHWAYS IN THE ENDOCRINOLOGY OF PARTURITION

F A Anca1

  • 1"Carol Davila" University of Medicine and Pharmacy, Obstetrics and Gynecology Dept., University Emergency Hospital, Bucharest, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed

The entire complex process of labor is the central concern of obstetrics and premature labor poses a threat to the mother and fetus and represents a core medical and social issue. In this respect, understanding the mechanism of uterine contractions at a molecular level helps shed some light on possible future prevention and treatment. New research has emphasized the role of endocannabinoids by two metabolic pathways with final products that act as antagonists: prostaglandins and prostamides (prostaglandin-ethanolamides), but with competition on substrates and enzymes. Thus, the dominant pathway will be selected on account of cellular and tissue environment.

Keywords:
contractilityendocannabinoidinflammationpremature laborprostaglandinsprostamide

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