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THYROID DYSFUNCTION AND INFERTILITY TREATMENT.

S Lalani1, I Nizami1, A A Hashmi1

  • 1Aga Khan University, Karachi, Pakistan.

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Summary
This summary is machine-generated.

Elevated thyroid hormones (T3 and T4) in women undergoing intracytoplasmic sperm injection (ICSI) are linked to poorer fertility outcomes. This suggests thyroid function impacts implantation success in assisted reproduction.

Keywords:
Assisted reproductive techniqueHigh levels of thyroxinInfertilityIntracytoplasmic sperm injectionThyroid profile

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Area of Science:

  • Reproductive Endocrinology
  • Infertility Research

Background:

  • Thyroid hormones play a crucial role in female reproductive health.
  • Suboptimal thyroid function can affect fertility and pregnancy outcomes.

Purpose of the Study:

  • To investigate the association between thyroid hormone profiles (T3, T4, TSH) and ICSI outcomes in infertile women.
  • To determine if thyroid hormone levels correlate with key pregnancy indicators.

Main Methods:

  • A cross-sectional study involving 168 infertile women undergoing ICSI.
  • Measurement of serum triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) levels.
  • Comparison of thyroid hormone levels between pregnant and non-pregnant groups using statistical tests.

Main Results:

  • Non-pregnant women exhibited significantly higher mean T3 and T4 levels compared to pregnant women (p <0.05, p<0.01).
  • No significant difference in mean TSH levels was observed between the groups (p=0.08).
  • Thyroxine (T4) showed a significant negative correlation with embryo grading, blastocyst formation, endometrial thickness, and gestational sac number.

Conclusions:

  • Altered thyroid profiles, particularly elevated T4 levels, are associated with reduced endometrial thickness and lower embryo quality.
  • These thyroid-related changes may negatively impact implantation and conception rates in women undergoing ICSI.