Related Experiment Video
Updated: Jan 24, 2026

07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.5K
SERUM LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 IN MALES WITH METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA
Summary
Lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are elevated in patients with metabolic syndrome (MetS) and obstructive sleep apnea syndrome (OSAS), indicating increased vascular inflammation and potential cardiovascular disease risk.
Area of Science:
- Cardiology
- Sleep Medicine
- Biomarkers
Background:
- Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a biomarker for cardiovascular disease (CVD) risk.
- Limited research exists on Lp-PLA2 in patients with metabolic syndrome (MetS) and obstructive sleep apnea syndrome (OSAS).
Purpose of the Study:
- To assess Lp-PLA2 as a marker of vascular inflammation in patients with MetS and OSAS.
- To evaluate the contribution of Lp-PLA2 to cardiometabolic dysfunction in this population.
Main Methods:
- Prospective case-control study involving 83 men.
- Measurements included anthropometrics, laboratory analysis, and overnight sleep studies.
- Serum Lp-PLA2 levels were quantified using ELISA and patients were grouped by MetS and OSAS status.
Main Results:
- Lp-PLA2 levels differed significantly across the three groups (MetS, OSAS with/without MetS).
- Higher Lp-PLA2 was observed in OSAS patients with MetS.
- Lp-PLA2 positively correlated with C-reactive protein (CRP) and apnea-hypopnea index (AHI); negatively with oxygen saturation.
Conclusions:
- Lp-PLA2 levels are linked to OSAS severity.
- Lp-PLA2 may be a valuable predictor of CVD in patients with OSAS, with or without MetS.
Related Concept Videos
Sleep Apnea
504
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
504
Insufficient Sleep and Sleep Deprivation
858
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
858
What is Metabolism?
131.4K
Overview
131.4K
Infertility in Males
540
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
540
Stages of Sleep
1.3K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.3K
Understanding Sleep
1.4K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.4K

