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Development of Organoids from Mouse Pituitary as In Vitro Model to Explore Pituitary Stem Cell Biology
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A RARE CAUSE OF PITUITARY APOPLEXY: CABERGOLINE THERAPY.

B Aydin1, O Aksu2, H Asci3

  • 1Adiyaman State Hospital, Endocrinology and Metabolic Disease, Adiyaman, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed
Summary
This summary is machine-generated.

Pituitary apoplexy (PA) is a serious condition. Cabergoline, a common treatment for prolactinomas, may increase the risk of PA, especially in cystic macroprolactinomas, as seen in a recent patient case.

Keywords:
Pituitary apoplexycabergolinecystic macroprolactinoma

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Area of Science:

  • Endocrinology
  • Neuroscience
  • Oncology

Background:

  • Pituitary apoplexy (PA) is a critical medical emergency.
  • Dopamine receptor agonists, like cabergoline, are primary treatments for prolactinomas.
  • Cabergoline's association with PA risk, particularly in cystic macroprolactinomas, warrants further investigation.

Observation:

  • A patient with a cystic macroprolactinoma was treated with cabergoline.
  • The patient developed pituitary apoplexy (PA) during the 16th week of cabergoline therapy.

Findings:

  • This case highlights a potential link between cabergoline treatment and the onset of PA in patients with cystic macroprolactinomas.
  • The specific characteristics of the macroprolactinoma may influence the risk of developing PA under cabergoline therapy.

Implications:

  • Clinicians should be vigilant for PA symptoms in patients with cystic macroprolactinomas receiving cabergoline.
  • Further research is needed to elucidate the mechanisms underlying cabergoline-induced PA and to refine treatment guidelines.