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ENDOTHELIAL DYSFUNCTION IN ACROMEGALIC PATIENTS: A CASE-CONTROL STUDY

S Ghiorghe1, A Dragomir2, D Bartos3

  • 1"Policlinico di Monza" Medical Center, Dept. of Cardiology, Bucharest, Romania.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed

Insights

Cardiovascular risk in acromegaly patients is better assessed by endothelial dysfunction than traditional factors. Growth hormone levels significantly correlate with this dysfunction, suggesting a unique risk evaluation approach.

Area of Science:

  • Endocrinology
  • Cardiology
  • Vascular Medicine

Background:

  • Traditional cardiovascular risk factors are insufficient for assessing risk in acromegaly patients.
  • Endothelial dysfunction is proposed as a more accurate indicator of cardiovascular risk in acromegaly.

Observation:

  • The study compared endothelial dysfunction in 54 acromegaly patients and 64 hypertensive patients using flow-mediated dilation (FMD).
  • Endothelial dysfunction was more prevalent in the acromegaly group (61.10%) compared to the hypertensive group (32.10%).
  • Higher growth hormone (GH) levels strongly correlated with endothelial dysfunction in acromegaly patients.

Findings:

  • Acromegaly patients exhibited a higher prevalence of endothelial dysfunction than hypertensive patients, despite fewer traditional cardiovascular risk factors.
  • Growth hormone (GH) levels showed the strongest correlation with endothelial dysfunction in the acromegaly cohort.
  • Traditional cardiovascular risk factors were less significant in predicting endothelial dysfunction in acromegaly.

Implications:

  • Cardiovascular risk assessment in acromegaly requires a different approach than in the general population.
  • Monitoring GH levels is crucial for managing cardiovascular risk in acromegaly.
  • Further research into tailored cardiovascular risk management strategies for acromegaly is warranted.
Abstract

Keywords:
Acromegalycardiovascular risk factorsendothelial dysfunction

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