EFFECTIVENESS OF ANETHUM GRAVEOLENS L. ON ANTIOXIDANT STATUS, THYROID FUNCTION AND HISTOPATHOLOGY.

Area of Science:

• Pharmacology
• Endocrinology
• Herbal Medicine

Background:

• Anethum graveolens L. (dill) is traditionally used for various ailments.
• Limited research exists on the effects of Anethum graveolens L. on thyroid tissue.

Purpose of the Study:

• To investigate the functional and histopathological effects of Anethum graveolens L. extract on rat thyroid tissue.
• To assess changes in thyroid hormones and antioxidant status following Anethum graveolens L. administration.

Main Methods:

• An experimental 30-day study involving 28 female Wistar Albino rats.
• Rats received daily gavage of Anethum graveolens L. extract at doses of 0, 50, 150, and 300 mg/kg.
• Thyroid function (fT3, fT4, TSH), antioxidant efficiency, and thyroid histology were evaluated.

Main Results:

• No significant changes in fT3, fT4, or TSH were observed in rats receiving lower doses (0, 50, 150 mg/kg).
• The highest dose (300 mg/kg) led to a significant decrease in TSH levels and increased thyroid follicular cell hypertrophy and hyperplasia.
• Antioxidant efficiency remained unchanged across all experimental groups.

Conclusions:

• Anethum graveolens L. extract influences thyroid function and histology in a dose-dependent manner.
• The extract demonstrated efficacy in altering thyroid tissue but did not impact the measured antioxidant status.
• Further research is warranted to elucidate the specific mechanisms of action on thyroid tissue.