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THE EFFECTS OF OPIUM ADDICTION ON THYROID AND SEX HORMONES IN DIABETIC AND NON-DIABETIC MALE AND FEMALE RATS
G Asadikaram1, H Akbari2, S Vakili1,3
1Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
Summary
Chronic opium use impacts hormone levels differently in male and female rats, with effects varying based on diabetes status. Opium alters thyroid and sex hormones, affecting the endocrine system in a sex-specific manner.
Area of Science:
- Endocrinology
- Pharmacology
- Toxicology
Background:
- Opium and its derivatives are potent narcotics with known metabolic and tolerability issues.
- Understanding the endocrine-disrupting effects of opium is crucial due to its abuse potential.
Purpose of the Study:
- To investigate the impact of chronic opium consumption on sexual and thyroid hormones.
- To compare these effects in diabetic versus non-diabetic male and female rats.
Main Methods:
- An experimental study involving 56 Wistar rats divided into four groups: diabetic addicted (DA), diabetic non-addicted (DNA), non-diabetic addicted (NDA), and non-diabetic non-addicted (NDNA).
- Hormone levels (thyroid and sex hormones) were measured from peripheral blood samples.
- Statistical analysis using Student's t-test was performed to compare hormone levels between groups.
Main Results:
- Opium consumption increased T3 serum levels in both diabetic and non-diabetic male rats.
- Testosterone levels decreased in male rats but increased in diabetic and non-diabetic female rats with opium use.
- Opium affected 17-hydroxyprogesterone and DHEA-S levels in a sex- and diabetes-dependent manner.
Conclusions:
- Opium exerts a sex-dependent influence on the endocrine system.
- The effects of opium on hormone levels are modulated by diabetic conditions.
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