Related Experiment Video

Updated: Jan 24, 2026

Imaging Dpp Release from a Drosophila Wing Disc
06:12

Imaging Dpp Release from a Drosophila Wing Disc

Published on: October 30, 2019

6.1K

DPP-4 INHIBITORS INCREASE THE INCIDENCE OF ARTHRITIS/ARTHRALGIA BUT DO NOT AFFECT AUTOIMMUNITY

Z A Sayiner1, B Okyar2, B Kısacık3

  • 1Gaziantep University School of Medicine, Dept. of Endocrinology and Metabolism, Gaziantep, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed
Abstract

Insights

DPP-4 inhibitors, used for type 2 diabetes, are linked to increased joint pain incidence. This study found a higher risk of arthritis/arthralgia in users, but no difference in autoimmune markers.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Pharmacology

Background:

  • FDA issued a black box warning in 2015 regarding DPP-4 inhibitors and severe joint pain.
  • The effect of DPP-4 inhibitors on autoimmunity markers in patients with type 2 diabetes (T2DM) requires further investigation.

Purpose of the Study:

  • To compare the incidence of arthritis/arthralgia in T2DM patients using DPP-4 inhibitors versus non-users.
  • To evaluate the impact of DPP-4 inhibitors on autoimmunity marker positivity.

Main Methods:

  • Retrospective study comparing 93 DPP-4 inhibitor users and 107 non-users with T2DM.
  • Incidence of arthritis/arthralgia and seropositivity for rheumatological conditions were assessed.

Main Results:

  • Arthritis/arthralgia occurred in 44.1% of DPP-4 inhibitor users vs. 17.8% of non-users (p<0.05).
  • No significant difference in inflammatory rheumatological conditions or seropositivity was observed between groups.
  • Adjusted analysis revealed a significantly increased incidence of arthritis/arthralgia in DPP-4 inhibitor users (p<0.05).
  • The risk of arthritis/arthralgia was 3.77 times higher in DPP-4 inhibitor users (p=0.001), increasing by 2.43 times per year of use.

Conclusions:

  • Arthritis/arthralgia are more common in T2DM patients using DPP-4 inhibitors compared to non-users.
  • DPP-4 inhibitor use did not significantly affect seropositivity for autoimmune markers.
Keywords:
DPP-4 inhibitorsType 2 Diabetes Mellitusarthralgia/arthritis

More Related Videos

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue09:42

A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue

Published on: June 7, 2017

12.0K
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

1.1K

Related Concept Videos

Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
616
Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
1.7K
Role of Affect in Interpersonal Attraction01:24

Role of Affect in Interpersonal Attraction

Affect plays a crucial role in shaping interpersonal evaluations and perceptions. Emotions influence how individuals judge and respond to others, often determining whether interactions are viewed positively or negatively. This effect can manifest directly through interactions with the person in question or indirectly via associations with unrelated emotional experiences.Direct Effects of Affect on AttractionAffect directly influences interpersonal attraction when a person’s behavior...
218
The Influence of Affect on Cognition01:29

The Influence of Affect on Cognition

Positive affect significantly influences cognitive processes, including evaluation, memory, creativity, and social judgments. Compared to negative affect, positive emotional states promote more favorable interpretations of stimuli, cognitive flexibility, and heuristic processing. These effects highlight emotions' powerful role in shaping how individuals perceive, remember, and interact with the world.Influence on Evaluation and AttributionWhen individuals experience positive affect, they are...
272
The Influence of Cognition on Affect01:29

The Influence of Cognition on Affect

Cognition plays a pivotal role in shaping emotional experiences, as demonstrated by Schachter and Singer’s two-factor theory of emotion. According to this model, emotion arises from a combination of physiological arousal and cognitive interpretation. The body’s physiological response to stimuli is ambiguous and only gains emotional significance through cognitive labeling. For instance, an increased heart rate and adrenaline surge while standing near an attractive person may be...
195
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
10.9K