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Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
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RED CELL DISTRIBUTION WIDTH AND ACUTE COMPLICATIONS OF DIABETES.

H Atalay1, B Boyuk2, M Ates2

  • 1Gebze Government Hospital, Dept. of Internal Medicine, Izmit, Turkey.

Acta Endocrinologica (Bucharest, Romania : 2005)
|June 1, 2019
PubMed
Summary

Red cell distribution width (RDW) and RDW/MCV ratio can help predict diabetic ketoacidosis (DKA) in type 2 diabetes (T2DM) patients. These markers are associated with DKA but not useful for predicting hyperglycemic hyperosmolar non-ketotic acidosis (HONK).

Keywords:
HONKdiabetic ketoacidosisrdw

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Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
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Area of Science:

  • Endocrinology
  • Hematology
  • Clinical Diagnostics

Background:

  • Red cell distribution width (RDW) is linked to type 2 diabetes (T2DM).
  • Data on RDW's role in diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar non-ketotic acidosis (HONK) is limited.
  • Understanding these associations can improve T2DM complication management.

Purpose of the Study:

  • To investigate the relationship between RDW, mean corpuscular volume (MCV), and the RDW/MCV ratio with acute complications in T2DM.
  • To assess the predictive value of these red blood cell indices for DKA and HONK.
  • To determine optimal cut-off values for RDW, MCV, and RDW/MCV in identifying DKA.

Main Methods:

  • RDW and MCV were analyzed in 90 T2DM patients: 30 with DKA, 30 with HONK, and 30 without acute complications.
  • Statistical analyses included One-Way ANOVA, Kruskal-Wallis, and Pearson correlation using SPSS.
  • Receiver operating characteristic (ROC) curve analysis was employed to establish diagnostic cut-off points.

Main Results:

  • DKA patients exhibited significantly higher plasma glucose, HbA1c, osmotic pressure, RDW, and RDW/MCV ratio compared to HONK patients.
  • The RDW/MCV ratio showed a cut-off of 0.15 with 90% sensitivity and 50% specificity for DKA prediction.
  • ROC analysis indicated that RDW and RDW/MCV ratio were significant predictors of DKA (AUC 0.708 and 0.766, respectively).

Conclusions:

  • RDW and the RDW/MCV ratio are significantly associated with DKA in T2DM patients.
  • These red blood cell indices demonstrate potential as valuable predictors for identifying DKA.
  • RDW and RDW/MCV ratio were not found to be valuable in predicting HONK.