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Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

4.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
4.7K
Routes of Drug Administration: Enteral01:18

Routes of Drug Administration: Enteral

6.4K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
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Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

666
The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
The absorption exponent (ka) indicates the speed at which the drug...
666
Routes of Drug Administration: Parenteral01:25

Routes of Drug Administration: Parenteral

2.8K
The administration of drugs via parenteral routes allows for direct drug introduction into the systemic circulation, resulting in high bioavailability because the medication bypasses the harsh conditions of the gastrointestinal tract and hepatic metabolism.
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
2.8K
Routes of Drug Administration: Overview01:22

Routes of Drug Administration: Overview

9.4K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
9.4K
Acute Pharyngitis01:30

Acute Pharyngitis

4.0K
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
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Related Experiment Video

Updated: Jan 24, 2026

A Cell Free Assay System Estimating the Neutralizing Capacity of GM-CSF Antibody using Recombinant Soluble GM-CSF Receptor
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A Cell Free Assay System Estimating the Neutralizing Capacity of GM-CSF Antibody using Recombinant Soluble GM-CSF Receptor

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Acute arteritis after G-CSF administration.

Yasuyuki Kinjo1, Tomoko Kurita1, Taeko Ueda1

  • 1Department of Obstetrics and Gynecology, University of Occupational and Environmental Health, Iseigaoka1-1, Yahatanishi-ku, Kitakyushu, Fukuoka Japan.

International Cancer Conference Journal
|June 1, 2019
PubMed
Summary

Granulocyte colony-stimulating factor (G-CSF) can rarely cause acute arteritis. This case highlights a potential G-CSF side effect in a patient treated for ovarian cancer, emphasizing the need for careful diagnosis.

Area of Science:

  • Oncology
  • Hematology
  • Vascular Medicine

Background:

  • Granulocyte colony-stimulating factor (G-CSF) is a myeloid growth factor used to accelerate neutropenia recovery post-chemotherapy.
Keywords:
AortitisArteritisG-CSFSide effect

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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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  • Arteritis is an extremely rare, but potential, adverse effect of G-CSF therapy.
  • Ovarian cancer patients undergoing chemotherapy are at risk for neutropenia.