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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Transepidermal Water Loss in Psoriasis: A Case-control Study.

Vrushali N Nikam¹, Rochelle C Monteiro¹, Sukumar Dandakeri¹

¹Department of Dermatology, Father Mullers Medical College, Mangalore, Karnataka, India.

Indian Dermatology Online Journal

|June 1, 2019

Summary

Psoriasis patients exhibit impaired skin barrier function, with significantly higher Transepidermal Water Loss (TEWL) in both affected and unaffected skin compared to healthy controls. This indicates compromised skin hydration and barrier integrity in psoriasis.

Keywords:

Barrier function psoriasis transepidermal water loss

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Area of Science:

Dermatology
Skin Physiology
Biomedical Engineering

Background:

Psoriasis is a common skin disorder marked by rapid skin cell growth and impaired skin barrier function.
Transepidermal Water Loss (TEWL) is a key non-invasive metric for assessing skin barrier integrity.

Purpose of the Study:

To quantify skin barrier function changes in psoriasis using TEWL measurements.
To investigate TEWL differences between lesional and non-lesional psoriatic skin.
To compare TEWL in psoriatic lesions versus matched control sites.

Main Methods:

TEWL was measured using the VapoMeter closed chamber method on 50 psoriasis patients and controls.
Measurements were taken on involved plaques, uninvolved skin, and site-matched control areas (ankle, elbow).
Statistical analysis included Shapiro-Wilk and Mann-Whitney tests.

Main Results:

Psoriatic skin showed significantly higher TEWL across all measured sites compared to controls, indicating overall barrier dysfunction.
Lesional psoriatic skin exhibited higher TEWL than non-lesional psoriatic skin.
Results suggest reduced water-holding capacity in psoriatic plaques.

Conclusions:

Psoriasis is characterized by a compromised skin barrier with elevated TEWL in both lesional and non-lesional skin.
TEWL is a reliable, objective, and non-invasive tool for assessing skin barrier function in psoriasis.