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Updated: Jan 24, 2026

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
Published on: October 5, 2020
EGFR Inhibitors-related Panniculitis: A New Side Effect
Sofia Lopes1, Ana Nogueira1, Joana Pardal2
1Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Porto, Portugal.
Abstract:
Epidermal growth factor receptor (EGFR) inhibitors are widely used in the treatment of advanced malignancies, and their skin toxicity is frequent and well recognized in the literature. We report the case of a 69-year-old patient with a history of adenocarcinoma of the lung treated with several EGFR inhibitors and the development of skin lesions compatible with panniculitis. The reproducibility of the lesions with different inhibitors reinforces the causal relationship with the drug, representing the first report in the literature of this side effect.
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