[Effect of benzodiazepine receptor blockade on memory processes in the mouse]

The results of study testify to a stimulating effect of benzodiazepine receptors blocators RO15-1788 and RO15-3505 on reproduction of conditioned reaction of passive avoidance in mice disturbed as a result of various procedures-"psychogenic" and cycloheximide amnesia, extinction and forgetting. A considerable antiamnesic effect of the drugs on cycloheximide amnesia models is noted, in comparison with the "psychogenic" one. RO15-3505 is more effective in the processes of extraction of memory traces under amnesia. The obtained results testify to an important contribution of benzodiazepine-GABA-ergic brain systems in inhibitory regulation of the processes of stored memory traces reproduction.