Effects of long-term parenteral nutrition on gastrin release in dogs

The effects of long-term total parenteral nutrition (TPN) on gastrin release were evaluated in dogs. The antral mucosal gastrin level was also measured before and after TPN. Longterm TPN reduced the mucosal gastrin levels, so that the serum gastrin release was depressed depending on time. However, the reduced levels gradually recovered after resumption of oral feeding. Diminished values had almost returned to pre-TPN levels by the 7th day.