Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.3K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.3K
Cancer02:18

Cancer

53.8K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.8K
What is Cancer?02:12

What is Cancer?

14.1K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.1K
Cancer Prevention02:59

Cancer Prevention

7.7K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.7K
Cancer Therapies02:49

Cancer Therapies

9.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Cancer Vaccines01:30

Cancer Vaccines

985
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
985

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advancing precision therapy in pediatric acute myeloid leukemia through PDX models and mitochondrial targeting.

Blood advances·2026
Same author

Italian clinical practice GRADE-based guidelines on the diagnosis and treatment of overweight and obesity, endorsed by the Italian National Institute of Health.

Eating and weight disorders : EWD·2026
Same author

Late-onset Pompe's disease in pediatrics: results from an Italian national survey on 38 patients and proposal of a targeted diagnostic algorithm.

Orphanet journal of rare diseases·2025
Same author

Correction: Development of the Italian clinical practice guideline on diagnosing and treating obesity in adults: scope and methodological aspects.

Eating and weight disorders : EWD·2025
Same author

Long-term outcome in Wiskott-Aldrich syndrome and X-linked thrombocytopenia patients: an observational -prospective multi-center study of the Italian Primary Immune Deficiency Network (IPINET).

EClinicalMedicine·2025
Same author

Consumptive hypothyroidism complicating infantile hepatic hemangioma successfully treated with propranolol: a case report and literature review.

Italian journal of pediatrics·2025

Related Experiment Video

Updated: Jan 24, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K

BCOR involvement in cancer.

Annalisa Astolfi1, Michele Fiore2, Fraia Melchionda2

  • 1'Giorgio Prodi' Cancer Research Center, University of Bologna, 40138 Bologna, Italy.

Epigenomics
|June 1, 2019
PubMed
Summary

The BCOR gene, an epigenetic regulator, drives various cancers including sarcomas and CNS tumors through specific gene fusions and mutations. Understanding BCOR alterations is key to cancer research and treatment development.

Keywords:
BCORCCSKCNS-HGNET-BCORESSITDPRC1.1PRC2SRBCSepigeneticsoncogenesis

More Related Videos

Using Eye Movements to Evaluate the Cognitive Processes Involved in Text Comprehension
06:49

Using Eye Movements to Evaluate the Cognitive Processes Involved in Text Comprehension

Published on: January 10, 2014

28.0K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.1K

Related Experiment Videos

Last Updated: Jan 24, 2026

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K
Using Eye Movements to Evaluate the Cognitive Processes Involved in Text Comprehension
06:49

Using Eye Movements to Evaluate the Cognitive Processes Involved in Text Comprehension

Published on: January 10, 2014

28.0K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.1K

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Oncology

Background:

  • The BCOR gene encodes an epigenetic regulator crucial for cell differentiation and development.
  • BCOR functions within the noncanonical polycomb repressive complex 1.
  • Aberrations in BCOR are increasingly recognized in various human cancers.

Purpose of the Study:

  • To provide a comprehensive review of BCOR's role in oncology.
  • To summarize key BCOR alterations and their associated tumor types.
  • To highlight the significance of BCOR in cancer evolution.

Main Methods:

  • Literature review of studies on BCOR gene alterations in cancer.
  • Analysis of specific BCOR aberrations, including gene fusions and mutations.
  • Correlation of BCOR alterations with distinct sarcoma and central nervous system (CNS) tumor classifications.

Main Results:

  • Specific BCOR aberrations, such as internal tandem duplications and gene fusions (e.g., BCOR-CCNB3), are driver events in sarcomas like clear cell sarcoma of the kidney and endometrial stromal sarcoma.
  • BCOR alterations are implicated in the pathogenesis of CNS-HGNET-BCOR, a group of heterogeneous CNS neoplasms.
  • Loss-of-function BCOR mutations are recurrent across a wide spectrum of mesenchymal, epithelial, neural, and hematological tumors.

Conclusions:

  • BCOR plays a central role in the development and evolution of diverse cancers.
  • Identifying BCOR alterations is critical for accurate tumor classification and understanding oncogenesis.
  • Targeting BCOR pathways may offer novel therapeutic strategies for various malignancies.