Related Experiment Video
Updated: Jan 24, 2026
12:32
Quantification of Plasmid-Mediated Antibiotic Resistance in an Experimental Evolution Approach
Published on: December 14, 2019
14.6K
Antibiotic resistance breakers: current approaches and future directions
Mark Laws1, Ali Shaaban1, Khondaker Miraz Rahman1
1Institute of Pharmaceutical Sciences, School of Cancer and Pharmaceutical Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH.
FEMS Microbiology Reviews
|June 1, 2019
Summary
Antibiotic resistance breakers (ARBs) offer a promising strategy to combat resistant infections. Further research into diverse ARB classes could yield more effective treatments, preventing a return to pre-antibiotic medicine.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Antimicrobial resistance (AMR) is a growing global health threat.
- Novel strategies are crucial to prevent a return to pre-penicillin medical era.
- Antibiotic resistance breakers (ARBs) can re-sensitize bacteria to antibiotics.
Purpose of the Study:
- To introduce the field of ARB research.
- To summarize current ARB development and classes.
- To provide a perspective on future ARB research directions.
Main Methods:
- Literature review of existing ARB research.
- Analysis of different classes of ARBs and their mechanisms of action.
- Discussion of clinical applications and future potential.
Main Results:
- Several classes of ARBs are under investigation.
- ARBs demonstrate potential in overcoming specific resistance mechanisms.
- Existing ARBs like beta-lactamase inhibitors show clinical utility.
Conclusions:
- The field of ARB research holds significant potential for developing novel therapeutics.
- Exploring a wider diversity of ARBs may lead to more effective agents than currently available.
- Continued research is essential to fully harness the therapeutic power of ARBs against resistant pathogens.
Keywords:
ESKAPEEantibiotic resistance breakersbeta-lactamase inhibitorscombination therapyefflux pump inhibitorsmembrane permeabilisersMore Related Videos
Related Concept Videos
01:30Development of Antibiotic Resistance
1.4K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.4K
00:57Antibiotic Selection
59.6K
Overview
59.6K
01:23Circuit Breaker and Fuse Selection
583
A circuit breaker is a device engineered to interrupt fault currents and sometimes reclose automatically. When a fault current is detected, the breaker separates the electrical contacts, which generates an arc. This arc is extinguished by methods such as elongation, cooling, or splitting, depending on the breaker's design. Breakers are categorized based on the voltage they operate at and the medium used for arc extinction, such as air, oil, SF6 gas, or vacuum.
In high-voltage systems,...
In high-voltage systems,...
583
01:22Resistivity
4.4K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.4K
01:19Resistance
5.7K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.7K
01:10Electrical Current
6.9K
Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
6.9K