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Synthesis of Bimetallic Pt/Sn-based Nanoparticles in Ionic Liquids
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Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms
Hywel D Williams1, Leigh Ford1, Annabel Igonin2
1Oral Drug Delivery Innovation, Global Research & Development, Lonza, Monash University, 381 Royal Parade, Parkville, Victoria, Australia.
Advanced Drug Delivery Reviews
|June 1, 2019
Summary
A novel lipophilic salt strategy enhances lipid-based formulations (LBFs) for oral drug delivery. This approach improves drug absorption, reduces variability, and addresses challenges with modern pharmaceuticals.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Lipid-based formulations (LBFs) are established for oral drug delivery.
- Current LBFs require innovation to meet the demands of modern drugs and optimize pharmacokinetics.
Purpose of the Study:
- To introduce a new lipophilic salt/ionic liquid approach for LBFs.
- To demonstrate how this strategy can tailor drug properties for improved LBF performance.
Main Methods:
- Review of lipophilic salt strategies in combination with LBFs.
- Discussion of synthesis, scale-up, formulation design, and regulatory considerations.
Main Results:
- Lipophilic salts offer advantages for dose escalation and reducing pill burden.
- This approach can enhance absorption of new drugs and aid life-cycle management.
Conclusions:
- The lipophilic salt strategy provides a method to optimize LBFs for a wider range of drugs.
- This innovation addresses challenges in achieving desired pharmacokinetic profiles and regulatory approval.
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