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Mapping cerebral perfusion from time-resolved contrast-enhanced MR angiographic data
Muhammad Asaduddin1, Won-Joon Do1, Eung Yeop Kim2
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.
Magnetic Resonance Imaging
|June 1, 2019
Summary
This study demonstrates that time-resolved contrast-enhanced magnetic resonance angiography (CE-MRA) can effectively derive perfusion parameters like cerebral blood volume (CBV) and Tmax. This single-contrast-agent method offers a promising alternative for stroke imaging.
Area of Science:
- Radiology
- Medical Imaging
- Neuroscience
Background:
- Conventional stroke imaging often requires separate MRI scans for angiography and perfusion.
- This necessitates multiple contrast agent injections, increasing risks and costs.
Purpose of the Study:
- To derive perfusion parameters, specifically cerebral blood volume (CBV) and Tmax, from time-resolved contrast-enhanced magnetic resonance angiography (CE-MRA).
- To evaluate the feasibility of using CE-MRA for both vascular and perfusion imaging in ischemic stroke patients.
Main Methods:
- Performed time-resolved CE-MRA and DSC-MRI on seven ischemic stroke subjects.
- Modeled CE-MRA concentration functions using a modified gamma-variate function.
- Calculated and compared perfusion parameters (CBV, Tmax) between CE-MRA and DSC-MRI.
Main Results:
- CBV and Tmax maps derived from CE-MRA showed good agreement with DSC-MRI.
- Demonstrated the capability of time-resolved CE-MRA to provide quantitative perfusion information.
Conclusions:
- Time-resolved CE-MRA can serve as a dual-purpose imaging technique for both angiography and tissue perfusion mapping.
- This approach utilizes a single contrast agent injection, potentially enhancing patient safety, comfort, and reducing healthcare costs.
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