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Updated: Jan 24, 2026
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Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
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Multifunctional Platforms Based on Graphene Oxide and Natural Products
Alexa Croitoru1,2, Ovidiu Oprea3, Adrian Nicoara4,5
1Academy of Romanian Scientists, Spl. Independenței 54, 50085 Bucharest, Romania. croitoru.alexa@yahoo.com.
Medicina (Kaunas, Lithuania)
|June 2, 2019
Summary
Graphene oxide nanocarriers were synthesized and loaded with bioactive compounds for potential medical use. While gallic acid showed release, other agents adhered strongly, indicating promising drug delivery platform potential.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Graphene oxide (GO) possesses unique properties making it suitable for biomedical applications.
- GO can serve as a versatile nanocarrier for both hydrophilic and hydrophobic biomolecules.
Purpose of the Study:
- To synthesize graphene oxide (GO) nanocarriers.
- To load GO with bioactive substances (gallic acid, caffeic acid, limonene, nutmeg, and cembra pine essential oils) for potential therapeutic applications.
- To create multifunctional platforms for drug delivery.
Main Methods:
- Graphene oxide synthesis using the Hummers method.
- Loading of GO with selected biologically active agents.
- Characterization of GO platforms using FTIR, HPLC, TGA, SEM, TEM, and Raman spectroscopy.
Main Results:
- Gallic acid demonstrated 80% release within 10 days; other agents showed minimal release due to high affinity for GO.
- SEM revealed nanosheet formation and slight particle agglomeration.
- Raman spectroscopy confirmed adsorption of bioactive substances onto GO without degradation.
Conclusions:
- The developed GO-based platforms show potential as nanocarriers for drug delivery.
- Further in vitro and in vivo studies are warranted to explore the biological activities of these loaded agents.
- These findings support the exploration of GO nanocarriers for advanced medical applications.
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