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Related Experiment Video

Updated: Jan 24, 2026

Measuring and Mapping Patterns of Soil Erosion and Deposition Related to Soil Carbonate Concentrations Under Agricultural Management
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Managing coagulopathy following PPH.

Helen McNamara1, Shuba Mallaiah1

  • 1Department of Anaesthesia, Liverpool Women's NHS Trust, Crown St., Liverpool, L8 7SS, UK.

Best Practice & Research. Clinical Obstetrics & Gynaecology
|June 2, 2019
PubMed
Summary
This summary is machine-generated.

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Maintaining fibrinogen levels above 2 g/l is crucial for preventing postpartum hemorrhage progression. Viscoelastometry offers rapid insights, guiding targeted fibrinogen replacement for improved maternal outcomes.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Anesthesiology

Background:

  • Pregnancy induces a prothrombotic state, crucial for preventing coagulopathy.
  • Fibrinogen levels (4-6 g/l) in parturients typically prevent hypofibrinogenemia during postpartum hemorrhage (PPH).
  • Plasma fibrinogen levels below 2 g/l predict bleed progression and necessitate intervention.

Purpose of the Study:

  • To review the role of fibrinogen in postpartum hemorrhage.
  • To evaluate diagnostic tools for coagulation assessment in PPH.
  • To discuss optimal fibrinogen replacement strategies during pregnancy.

Main Methods:

  • Literature review focusing on fibrinogen management in PPH.
  • Comparison of laboratory coagulation tests with viscoelastometry (FIBTEM A5).
Keywords:
CoagulationFibrinogenPostpartum haemorrhagePregnancyThromboelastometry

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  • Analysis of blood product suitability for fibrinogen replacement.

    • Main Results:

    • Low fibrinogen levels (<2 g/l) are critical indicators in PPH.
    • Viscoelastometry (FIBTEM A5) provides rapid, relevant data correlating with fibrinogen.
    • Fibrinogen concentrate or cryoprecipitate are preferred over fresh frozen plasma for replacement.
    • Formulaic blood product administration is often excessive.

    Conclusions:

    • Targeted fibrinogen replacement, guided by viscoelastometry, is essential in PPH.
    • Further research is needed to establish optimal treatment thresholds and benefits.
    • Viscoelastometry-guided protocols show potential for reduced morbidity, though RCTs are pending.