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Cellular oncogenes and lymphocyte activation.

J Schneider-Schaulies, R Knauer, A Schimpl

    Behring Institute Mitteilungen
    |June 1, 1987
    PubMed
    Summary
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    Cellular proto-oncogenes c-myc and c-fos are expressed in mouse lymphocytes. C-myc is linked to cell activation and growth, while c-fos is induced by sample preparation, suggesting c-myc

    Area of Science:

    • Immunology
    • Molecular Biology
    • Oncology

    Background:

    • Normal mouse splenic B and T cells express cellular proto-oncogenes c-myc and c-fos.
    • Proto-oncogene expression is tightly regulated by transcriptional and post-transcriptional mechanisms.
    • Understanding these regulatory mechanisms is crucial for comprehending lymphocyte activation and potential oncogenesis.

    Purpose of the Study:

    • To investigate the differential expression and regulation of c-myc and c-fos in mouse splenic B and T cells.
    • To determine the role of c-myc and c-fos in lymphocyte activation, cell cycle transition, and potential oncogenic transformation.
    • To elucidate the regulatory mechanisms controlling proto-oncogene expression in lymphocytes.

    Main Methods:

    • Analysis of c-myc and c-fos gene expression in normal mouse splenic B and T cells.

    Related Experiment Videos

  • Investigation of gene expression kinetics in response to mitogens and cell activation.
  • Examination of transgenic mice with constitutive c-myc expression in lymphocyte lineage.

    • Main Results:

    • C-myc expression correlates with cell activation and growth competence, while c-fos expression is induced by sample preparation.
    • Differential regulation of c-myc and c-fos by transcriptional and post-transcriptional controls, varying independently.
    • Constitutive c-myc expression in transgenic lymphocytes affects proliferation-maturation balance, Ia expression, and predisposes to leukemia.

    Conclusions:

    • C-myc plays a significant role in lymphocyte activation and growth, unlike c-fos.
    • Fine-tuned regulation of c-myc is essential to prevent aberrant cell behavior and oncogenic transformation.
    • Aberrant c-myc expression can profoundly impact lymphocyte lineage, leading to developmental and oncogenic consequences.