Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alterations in Respiration II01:30

Alterations in Respiration II

1.7K
There are numerous types of normal and abnormal respiration. Based on ventilatory movements, breathing patterns are classified as regular, deep, or shallow. Examples include Biot's breathing, Cheyne-Stokes respiration, Kussmaul's breathing, hyperventilation, and hypoventilation. Each pattern is clinically significant and aids in evaluating patients.
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes...
1.7K
Altered States of Awareness01:06

Altered States of Awareness

1.0K
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
1.0K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

2.1K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
2.1K
What is a Sensory System?01:31

What is a Sensory System?

100.9K
Sensory systems detect stimuli—such as light and sound waves—and transduce them into neural signals that can be interpreted by the nervous system. In addition to external stimuli detected by the senses, some sensory systems detect internal stimuli—such as the proprioceptors in muscles and tendons that send feedback about limb position.
100.9K
Epigenetic Regulation01:46

Epigenetic Regulation

33.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.5K
Genetics of Speciation02:16

Genetics of Speciation

21.0K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Compartment-specific analysis reveals disrupted astrocytic calcium transients in anesthetized Alzheimer's disease mice.

Journal of Alzheimer's disease : JAD·2026
Same author

Incidental DWI-Positive Lesions in 2 Cohorts of CAA and CADASIL: Prevalence, Distribution, and Associations With Clinical Variables.

Neurology·2026
Same author

Longitudinal multiphoton imaging of cerebral amyloid angiopathy in response to anti-ApoE4 immunotherapy in mice.

Molecular neurodegeneration·2026
Same author

Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders.

Nature reviews. Neuroscience·2026
Same author

Neuropathological correlates of MRI-observed hypointense lesions in the APP23 mouse model of cerebral amyloid angiopathy.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Spatial Image Gradient Estimation From the Diffusion MRI Profile.

Magnetic resonance in medicine·2026

Related Experiment Video

Updated: Jan 24, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

13.9K

Different microvascular alterations underlie microbleeds and microinfarcts.

Susanne J van Veluw1,2, Ashley A Scherlek1, Whitney M Freeze1,3

  • 1MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.

Annals of Neurology
|June 2, 2019
PubMed
Summary

Cerebral amyloid angiopathy (CAA) can lead to brain bleeds or strokes through different pathways. Amyloid beta (Aβ) accumulation is key, but its location differs in microbleeds versus microinfarcts.

More Related Videos

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
05:06

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

873
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

4.2K

Related Experiment Videos

Last Updated: Jan 24, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images
08:39

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

Published on: November 20, 2015

13.9K
Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
05:06

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

Published on: February 28, 2025

873
Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs
10:00

Author Spotlight: Advances in Quantifying Microvascular Density in Aging Murine Lungs

Published on: January 3, 2025

4.2K

Area of Science:

  • Neuropathology
  • Neuroimaging
  • Cerebrovascular Disease

Background:

  • Cerebral amyloid angiopathy (CAA) involves amyloid-beta (Aβ) deposition in brain vessels, leading to microbleeds and microinfarcts.
  • The precise relationship between CAA severity and these lesions, and the underlying mechanisms, are not fully understood.

Purpose of the Study:

  • To investigate the association between CAA severity and the presence of microbleeds and microinfarcts.
  • To elucidate the distinct pathological pathways leading to hemorrhagic and ischemic lesions in CAA.

Main Methods:

  • Ex vivo magnetic resonance imaging (MRI) of 12 human brain hemispheres with CAA.
  • Histopathological examination of predefined and targeted areas with lesions.
  • Serial sectioning to analyze vessel wall composition at lesion sites.

Main Results:

  • No global association found between CAA severity and the number of microbleeds or microinfarcts.
  • Microbleeds showed minimal Aβ or smooth muscle cells at the bleeding site, with fibrin(ogen) common.
  • Microinfarcts consistently showed vascular Aβ at the core and surrounding areas, with few intact smooth muscle cells.

Conclusions:

  • CAA may cause hemorrhagic and ischemic brain lesions via two distinct mechanistic pathways.
  • Microbleeds appear primarily linked to vascular breakdown and fibrin deposition.
  • Microinfarcts are more directly associated with Aβ deposition within vessel walls.