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Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
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Posterior Reversible Encephalopathy Syndrome (PRES) in Children Undergoing Allogeneic Stem Cell Transplantation

Aleksandra Pivkova Veljanovska1, Zlate Stojanoski1, Lazar Chadievski1

  • 1University Clinic for Haematology, Bone Marrow Transplantation Unit, Medical faculty, University Ss. Cyril and Methodius,Skopje, Republic of Macedonia.

Prilozi (Makedonska Akademija Na Naukite I Umetnostite. Oddelenie Za Medicinski Nauki)
|June 2, 2019
PubMed

Insights

Posterior reversible encephalopathy syndrome (PRES) is a serious complication after pediatric stem cell transplants, often linked to immunosuppressants like cyclosporine. Early detection and monitoring are crucial for managing PRES and improving transplant outcomes in children.

Area of Science:

  • Pediatric Hematology/Oncology
  • Neuroscience
  • Transplantation Medicine

Background:

  • Posterior reversible encephalopathy syndrome (PRES) is a significant complication following allogeneic stem cell transplantation (ASCT) in children.
  • It is frequently associated with immunosuppressive therapies used during transplantation.

Observation:

  • A case study of a 7-year-old girl with myelodysplastic syndrome (MDS) who developed PRES post-ASCT.
  • PRES diagnosis was confirmed via imaging within the first month, strongly suggesting cyclosporine neurotoxicity.

Findings:

  • PRES contributes to increased transplant-related mortality in pediatric patients.
  • Cyclosporine-induced neurotoxicity is a likely cause of PRES in this case.

Implications:

  • Early identification of PRES risk factors and vigilant monitoring of vital signs (blood pressure, neurological status, vision) are essential.
  • This approach may allow for the use of immunosuppressive agents with lower neurological toxicity.
  • Further research is needed to confirm the impact of PRES on transplant outcomes.

Keywords:
PREScomplicationscyclosporineoutcomestem cell transplantation

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