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Updated: Jan 24, 2026

Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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A Core Outcome Set for the prevention and treatment of fetal GROwth restriction: deVeloping Endpoints: the COSGROVE

Patricia Healy1, Sanne J Gordijn2, Wessel Ganzevoort3

  • 1Health Research Board-Trials Methodology Research Network and the School of Nursing and Midwifery, National University of Ireland, Galway, Ireland.

American Journal of Obstetrics and Gynecology
|June 2, 2019
PubMed

Insights

A core outcome set was developed to standardize measurements in fetal growth restriction trials. This ensures consistent reporting and comparison of results for better prevention and treatment strategies.

Area of Science:

  • Obstetrics and Gynecology
  • Perinatology
  • Clinical Trial Methodology

Background:

  • Fetal growth restriction (FGR) impacts a fetus's ability to reach its genetic growth potential.
  • FGR is linked to increased risks of adverse short- and long-term health outcomes.
  • Variability in outcome reporting complicates evidence synthesis from FGR clinical trials.

Purpose of the Study:

  • To establish standardized core outcome sets for clinical trials focused on the prevention or treatment of FGR.

Main Methods:

  • A Delphi consensus study was employed, involving a literature review to identify reported outcomes.
  • Stakeholders including healthcare providers, researchers, and the public participated in three rounds of online surveys.
  • Consensus was achieved through predefined criteria at a face-to-face meeting.

Main Results:

  • A final core outcome set comprising 22 outcomes was established.
  • These outcomes are categorized into maternal (4), fetal (1), neonatal (12), and childhood (5) domains.

Conclusions:

  • The Core Outcome Set for the prevention and treatment of fetal GROwth restriction: deVeloping Endpoints (COS-FGROwth) study provides a minimum standard for outcome measurement in FGR trials.
  • Standardized measurement and reporting will enhance the comparability and combined analysis of findings across studies.
  • This facilitates more robust evidence generation for FGR interventions.
Abstract

Keywords:
core outcomefetal growth restrictiongestational agepregnancytrial

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