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Updated: Jan 24, 2026
09:07
Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses
Published on: June 14, 2020
11.6K
Imaging the execution phase of neuroinflammatory disease models
Adrian-Minh Schumacher1, Thomas Misgeld2, Martin Kerschensteiner3
1Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians Universität München, Munich, Germany; Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians Universität München, Martinsried, Germany.
Experimental Neurology
|June 2, 2019
Summary
Advanced in vivo imaging reveals how central nervous system cells respond to neuroinflammation in models of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). New tools track cell metabolism and interactions in chronic disease stages.
Area of Science:
- Neuroscience
- Immunology
- Cell Biology
Background:
- In vivo imaging of the rodent spinal cord is crucial for understanding neuroinflammation.
- Experimental autoimmune encephalomyelitis (EAE) is a key model for studying multiple sclerosis (MS).
- Neuroinflammation impacts CNS resident cells, axons, oligodendrocytes, and immune cell function.
Purpose of the Study:
- To explore cellular responses to neuroinflammation using advanced imaging techniques.
- To investigate mechanisms of axonal degeneration and oligodendrocyte damage in inflammatory lesions.
- To develop new biosensors and indicator mice for real-time monitoring of cellular states in neuroinflammation.
Main Methods:
- Utilizing two-photon imaging in rodent models.
- Employing experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS).
- Applying imaging to study antibody/complement-mediated neuromyelitis optica spectrum disease (NMOSD).
Main Results:
- Demonstrated how axons degenerate and oligodendrocytes are damaged in inflammatory lesions.
- Showcased adaptation of immune cell phenotype and function within the lesion environment.
- Highlighted the application of these methods to NMOSD and other neuroinflammatory conditions.
Conclusions:
- In vivo imaging provides critical insights into cellular dynamics during neuroinflammation.
- Ongoing development of biosensors and indicator mice will further advance understanding.
- Future research will focus on cortical gray matter inflammation and chronic disease stages in MS.
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