Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amnesia01:13

Amnesia

478
Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
478
Dissociative Amnesia01:21

Dissociative Amnesia

554
Dissociative amnesia is a complex psychological condition that manifests as an inability to recall personal information, often tied to traumatic or stressful events. Unlike general amnesia, individuals with this condition retain the ability to perform routine activities and procedural tasks, such as operating a phone or navigating public transportation, yet experience profound gaps in autobiographical memory. These lapses may encompass significant life events, such as suicide attempts or...
554
The Resting Membrane Potential01:21

The Resting Membrane Potential

142.0K
Overview
142.0K
Global Climate Change01:50

Global Climate Change

28.8K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.8K
Resting Potential Decay01:15

Resting Potential Decay

6.2K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
6.2K
Resting Membrane Potential01:24

Resting Membrane Potential

21.5K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
21.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep clinical, genetic, and serum biomarker profiling indicates glial and neuronal pathology in primary brain calcification.

Brain communications·2025
Same author

Neural, psychological, and daily life evidence for a transdiagnostic process of affective dysregulation in depression and chronic widespread pain.

Pain·2025
Same author

Multimodal Quantitative MRI Atlas of the Human Brain in Healthy Young Adults.

Journal of neuroimaging : official journal of the American Society of Neuroimaging·2025
Same author

The phenomenon of dynamic change of cardiac troponin levels in patients with spontaneous intracerebral hemorrhage increases in-hospital mortality independent of macrovascular coronary artery disease.

Journal of the neurological sciences·2025
Same author

Early processing of traumatic material and contextual information in posttraumatic stress disorder and its relation to memory impairments.

Scientific reports·2025
Same author

Hippocampal contributions to semantic memory retrieval: Strategy-specific impairments in transient global amnesia.

Journal of neuropsychology·2025

Related Experiment Video

Updated: Jan 24, 2026

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

7.1K

Resting-state connectivity alterations during transient global amnesia.

Francesca Zidda1, Martin Griebe2, Anne Ebert2

  • 1Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Neuroimage. Clinical
|June 2, 2019
PubMed
Summary
This summary is machine-generated.

Transient global amnesia (TGA) involves temporary memory loss due to brain network dysfunction. This study found reduced connectivity in the hippocampus and executive networks during acute TGA episodes.

Keywords:
Executive networkHippocampusMemoryResting-state functional connectivityTransient global amnesia

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.7K
Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

826

Related Experiment Videos

Last Updated: Jan 24, 2026

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
07:13

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

7.1K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.7K
Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
07:56

Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS

Published on: June 24, 2025

826

Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Neuroimaging

Background:

  • The pathophysiology of Transient Global Amnesia (TGA) remains unclear, though medial temporal lobe and hippocampal dysfunction are suspected.
  • Executive function disturbances have also been postulated in TGA patients.

Purpose of the Study:

  • To investigate brain network dynamics during the acute phase of TGA using resting-state functional MRI (fMRI).
  • To identify specific brain regions and networks affected in acute TGA.

Main Methods:

  • Prospective recruitment of 16 acute TGA patients from an emergency department.
  • Resting-state fMRI data acquired during the acute TGA stage.
  • Independent Component Analysis (ICA) applied to resting-state fMRI data for network analysis.
  • Comparison with 20 age- and sex-matched controls and 20 patients with a history of TGA.

Main Results:

  • Acute TGA patients exhibited severe anterograde episodic long-term memory deficits.
  • Group-based ICA revealed reduced functional connectivity (FC) in acute TGA patients within the executive network (EN), hippocampus, salience network, and other subcortical regions.
  • No significant connectivity differences were observed between patients with a history of TGA and controls.

Conclusions:

  • Findings support the involvement of hippocampal and executive network dysfunction in TGA pathophysiology.
  • Disruptions in frontal, parietal, and insular control regions, alongside hippocampal alterations, offer a new network-level interpretation of TGA.
  • This study provides insights into the large-scale network dynamics underlying TGA's neuropsychological profile.