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Author Spotlight: A Non-Invasive Tool to Assess and Differentiate Fat Patterns in Liver Using 3D Dixon MRI
Published on: October 20, 2023
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The association between liver fat and systemic calcified atherosclerosis
Bo Kyung Koo1, Matthew A Allison2, Michael H Criqui2
1Department of Family Medicine and Public Health, University of California San Diego, La Jolla, Calif; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
Journal of Vascular Surgery
|June 3, 2019
Summary
Nonalcoholic fatty liver disease (NAFLD) is linked to artery calcification, primarily through common risk factors. However, NAFLD shows an independent association with calcification in the thoracic aorta and celiac trunk.
Area of Science:
- Cardiovascular Medicine
- Hepatology
- Radiology
Background:
- Nonalcoholic fatty liver disease (NAFLD) association with systemic calcified atherosclerosis beyond coronary arteries is unclear.
- Investigated NAFLD's link to calcification across eight distinct vascular beds.
Purpose of the Study:
- To determine the association between NAFLD and arterial calcification in multiple vascular beds.
- To assess if this association persists after adjusting for traditional cardiovascular risk factors.
Main Methods:
- Community-based cohort study utilizing computed tomography (CT) scans.
- Evaluated calcification in eight arterial segments: coronary, carotid, thoracic aorta, abdominal aorta, iliac, renal, celiac trunk, and superior mesenteric arteries.
- Adjusted for age, sex, hypertension, dyslipidemia, diabetes, obesity, smoking, and family history of heart disease.
Main Results:
- NAFLD associated with calcification in coronary, carotid, thoracic aorta, celiac trunk, and superior mesenteric arteries (age/sex-adjusted).
- After risk factor adjustment, only thoracic aorta (OR 1.38) and celiac trunk (OR 2.05) showed significant association.
- NAFLD independently linked to multiarterial calcification (≥4 segments: OR 1.33, ≥5: OR 1.46, ≥6: OR 1.58).
Conclusions:
- NAFLD-arterial calcification link is largely mediated by conventional risk factors.
- Independent association of NAFLD with thoracic aorta and celiac trunk calcification requires further validation.
- Prospective studies in diverse populations are needed to confirm these findings.
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