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Historical aspects of probiotic use to prevent necrotising enterocolitis in preterm babies

Prudence Jarrett1, Andras Meczner1, Kate Costeloe2

  • 1Homerton University Hospital, NHS Foundation Trust, London, United Kingdom of Great Britain and Northern Ireland.

Early Human Development
|June 3, 2019
PubMed

Insights

Probiotic use in preterm infants for preventing necrotising enterocolitis shows mixed results. This review examines the history and reasons for inconsistent adoption in neonatal care.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Gastroenterology

Background:

  • Necrotising enterocolitis (NEC) is a serious condition affecting preterm infants.
  • Probiotics have been investigated for NEC prevention for decades.
  • Evidence for probiotic efficacy in NEC prevention is inconsistent.

Purpose of the Study:

  • To review the historical use of probiotics for NEC prevention in preterm infants.
  • To explore reasons for the uncertainty surrounding probiotic efficacy.
  • To understand why probiotics are not universally used in neonatal practice.

Main Methods:

  • Literature review of studies on probiotics for NEC prevention.
  • Analysis of early proof-of-concept studies.
  • Evaluation of observational studies and randomized controlled trials.

Main Results:

  • Probiotic administration has been explored through various study designs.
  • Some studies indicate potential benefits, while others show disappointing outcomes.
  • Lack of consistent results contributes to uncertainty.

Conclusions:

  • The efficacy of probiotics for NEC prevention in preterm infants remains debated.
  • Variability in study results and implementation challenges hinder universal adoption.
  • Further research may be needed to clarify optimal use and patient selection.

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