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Updated: Jan 24, 2026

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
Published on: March 5, 2019
Adipose Progenitor Cells Contribute to Lipid Spillover during Obesity
Nabil Rabhi1, Stephen R Farmer1
1Department of Biochemistry, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Abstract:
A recent study (Girousse et al. Cell Rep. 2019;27:323-333) shows that CXCR4+ adipose progenitors (APCs) contribute to lipid spillover during high-fat feeding through their release from subcutaneous fat depots (ScATs) and migration to skeletal muscle where they differentiate into adipocytes. Pharmacological antagonism of CXCR4, which prevents the CXCL12-dependent retention of APCs in ScAT, mimics the effects of overfeeding.
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