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Author Spotlight: Optimizing Growth Factors for Production of Biotechnologically Relevant Secondary Metabolites
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Association of circulating growth differentiation factor-15, Krüppel-like factor 4 and growth arrest-specific 6 with

Huan Liu1, Yong-Nan Lyu2, Di Li1

  • 1Department of Clinical Laboratory, Wuhan Univ, Renmin Hospital, Wuhan, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 3, 2019
PubMed

Insights

Novel biomarkers growth differentiation factor-15 (GDF-15) and Krüppel-like factor 4 (KLF4) show significant association with coronary artery disease (CAD) presence and severity in male patients.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • Current diagnostic tools for acute chest pain, such as coronary angiography and troponin measurements, have limitations.
  • Investigating novel cardiovascular stress markers is crucial for improving CAD assessment.
  • Growth differentiation factor-15 (GDF-15), Krüppel-like factor 4 (KLF4), and growth arrest-specific 6 (gas6) are novel biomarkers for cardiovascular stress.

Purpose of the Study:

  • To evaluate the utility of serum GDF-15, KLF4, and gas6 as potential biomarkers for coronary artery disease (CAD).
  • To determine the association of these novel markers with the presence and severity of CAD.

Main Methods:

  • A case-control study involving 350 male patients, with 198 diagnosed with CAD and 152 controls, confirmed by coronary angiography.
  • Serum concentrations of GDF-15, KLF4, and gas6 were measured using enzyme-linked immunosorbent assay kits.
  • Multivariate logistic and linear regression analyses were employed to assess the relationship between biomarker levels and CAD risk/severity.

Main Results:

  • Serum GDF-15 and KLF4 concentrations were significantly elevated in male patients with CAD compared to controls (P < .05).
  • Both GDF-15 and KLF4 levels correlated significantly with the extent of coronary vessel involvement (P < .05).
  • Adjusted analyses revealed that GDF-15 and KLF4 remained positively associated with CAD presence and severity (Gensini score), while gas6 showed no significant association.

Conclusions:

  • Elevated circulating concentrations of GDF-15 and KLF4 are significantly associated with both the presence and severity of coronary artery disease in male patients.
  • These findings suggest that GDF-15 and KLF4 may serve as valuable non-invasive biomarkers for CAD.
  • Further research is warranted to explore the clinical application of GDF-15 and KLF4 in diagnosing and managing CAD.
Abstract

Keywords:
Coronary artery diseaseGensini scoreGrowth arrest-specific 6Growth differentiation factor-15Krüppel-like factor 4

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