Consciousness in a multilevel architecture: What causes the lateralization of effective connectivity under resting...

Here we present our answers to a critical commentary by Elkhonon Goldberg on our recent publication (Velichkovsky et al., 2018). To avoid discussions about novelty effects in the human brain activity and memory processes, we narrowed down this response to a reanalysis of our data along the lines proposed in the commentary, namely to comparing the effective links between symmetrical brain structures during the first and the last parts of a prolonged resting-state fMRI experiment. We also tested for sex differences in our results and checked for a stability of top-down interactions during the course of experiment because learning is often expressed in the weakening of upper level control over low-level mechanisms. Our attempts to test the predictions based on the novelty hypothesis has led to mixed results suggesting that the discovered right-to-left dominance of causal connections at rest may have a deeper origin than supposed in the Goldberg's commentary.