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Updated: Jan 24, 2026

Isolation of Mouse Endometrial Epithelial and Stromal Cells for In Vitro Decidualization
Published on: March 2, 2017
Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise
Naveen K Neradugomma1, Kaitlyn Drafton1, Gil G Mor2
1Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
Abstract:
Marijuana (cannabis) use by pregnant women in the United States is increasing and there is a dire need to understand the beneficial or harmful effects of cannabis during pregnancy. Uterine endometrial stromal cells are fibroblast-like cells that differentiate into secretory cells, a process called decidualization, to create a microenvironment conducive for placenta formation and early embryonic growth. In this study, using model human cell lines, we for the first time demonstrate that Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) inhibit endometrial stromal cell decidualization and have adverse effects on trophoblast-endometrium cross-talk.
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