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06:39
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Accelerated progression of coronary artery disease
R J Vecht1, E P Nicolaides, A Duffett
1Department of Cardiology, Manor House Hospital, London.
British Medical Journal (Clinical Research Ed.)
|August 8, 1987
Summary
Atheromatous arterial disease can progress rapidly, leading to serious health risks. Current methods cannot identify patients at high risk for this rapid progression.
Area of Science:
- Cardiovascular Medicine
- Pathology
Background:
- Atheromatous disease of the arteries is a progressive condition associated with significant morbidity and mortality.
- The complex pathogenesis and variable progression rate of arterial lesions are not fully understood.
Purpose of the Study:
- To investigate the rate of progression of atheromatous disease in patients undergoing coronary arteriography.
- To observe changes in angiographic appearance over a short period.
Main Methods:
- Coronary arteriography was performed on six patients.
- Patients were restudied before percutaneous transluminal coronary angioplasty.
- Angiographic appearance was assessed for changes over time.
Main Results:
- Significant deterioration in angiographic appearance was observed in all six patients.
- The mean period for this deterioration was 3.6 months.
- Rapid progression of atheromatous disease poses a serious hazard.
Conclusions:
- Rapid progression of atheromatous arterial disease can occur over short timeframes.
- Identifying patients susceptible to rapid disease progression remains a challenge.
- Further research is needed to understand and predict rapid atheromatous disease progression.
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