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Published on: July 12, 2024
702
Myositis associated with carbon monoxide poisoning
Lindell K Weaver1,2,3, L Christine Oliver4, Kayla Deru1
1Division of Hyperbaric Medicine Intermountain Medical Center, Murray, Utah U.S>.
Summary
Carbon monoxide (CO) poisoning can cause myositis, a muscle inflammation. This case study highlights a truck driver who developed inflammatory myopathy after prolonged CO exposure, which resolved with treatment.
Area of Science:
- Neurology
- Toxicology
- Pathology
Background:
- Carbon monoxide (CO) poisoning is known to cause hypoxia and inflammation.
- Published literature lacks information on CO poisoning as a cause of myositis.
- This study investigates a potential link between CO exposure and inflammatory myopathy.
Observation:
- A 53-year-old female truck driver experienced prolonged CO exposure from faulty diesel exhaust.
- She developed neuropsychological symptoms, fatigue, weakness, myalgias, and was diagnosed with polymyositis.
- Elevated inflammatory markers and muscle biopsy confirmed severe inflammatory myopathy and myonecrosis.
Findings:
- The patient's myositis was attributed to CO poisoning, presenting as toxic inflammatory myopathy.
- Muscle inflammation and myonecrosis resolved after treatment with steroids and mycophenolate.
- Repeat muscle biopsy showed no signs of inflammation or myopathic process after 19 months.
Implications:
- This case suggests a potential etiological role for CO poisoning in the development of myositis.
- It underscores the importance of considering environmental toxins in diagnosing inflammatory myopathies.
- Further research is warranted to explore the mechanisms and prevalence of CO-induced myositis.
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