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Updated: Jan 24, 2026

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

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Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism

Amandine Verlande1, Selma Masri1

  • 1Department of Biological Chemistry, University of California, Irvine, CA 92697, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA 92867, USA; Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697, USA.

Trends in Endocrinology and Metabolism: TEM
|June 4, 2019
PubMed

Insights

The circadian clock regulates bodily rhythms. Its disruption is linked to cancer, influencing tumor growth through genetic and metabolic pathways.

Area of Science:

  • * Chronobiology
  • * Cancer Biology
  • * Metabolic Regulation

Background:

  • * The circadian clock governs physiological rhythms in virtually all cells.
  • * Disruption of this internal clock leads to systemic effects, notably cancer.
  • * Genetic clock disruption is increasingly linked to tumor initiation and progression.

Purpose of the Study:

  • * To outline major advances connecting the circadian clock and cancer metabolism.
  • * To discuss new research on metabolic flux in transformed cells.
  • * To explore the implications of circadian control on tumor metabolic heterogeneity.

Main Methods:

  • * Review of recent scientific literature and advances.
  • * Analysis of transcriptional and signaling networks.
  • * Examination of cellular metabolism in the tumor microenvironment and systemically.

Main Results:

  • * Circadian clock disruption significantly impacts cancer development.
  • * Metabolic pathways are crucial mediators of circadian control in cancer.
  • * Tumor metabolic heterogeneity is influenced by circadian regulation.

Conclusions:

  • * The circadian clock plays a critical role in cancer initiation and progression.
  • * Targeting circadian-controlled metabolic pathways presents a novel therapeutic strategy.
  • * Understanding these connections is vital for advancing cancer treatment and prevention.
Keywords:
circadian clock cancerepigeneticsmetabolismoncogenestumor suppressors

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