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Updated: Jan 24, 2026

Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
Published on: September 27, 2014
Ebola Virus Replication Stands Out
Wenjie Wang1, Chao Wu1, Gaya K Amarasinghe1
1Department of Pathology and Immunology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA.
Abstract:
A recent study by Deflubé et al. (Proc. Natl. Acad. Sci. U. S. A. 2019;116:8535-8543) reported that Ebola virus genomes have variable 3' terminal nucleotides. This finding is a departure from other nonsegmented, negative-strand RNA viruses (NNSVs) that have been studied to date and has broad implications for filoviral replication and innate immune evasion.
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