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Quantitative Susceptibility Mapping for Carotid Atherosclerotic Plaques: A Pilot Study
Yohei Ikebe1, Hideki Ishimaru1, Hiroshi Imai2
1Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences.
Summary
Quantitative susceptibility mapping (QSM) effectively differentiates carotid plaque components like hemorrhage and lipid necrosis. This novel MRI contrast aids in identifying vulnerable plaques for better patient outcomes.
Area of Science:
- Cardiovascular Imaging
- Neuroimaging
- Medical Physics
Background:
- Carotid atherosclerotic plaque vulnerability assessment relies on identifying intraplaque hemorrhage, lipid-rich necrosis, and calcification.
- Conventional magnetic resonance (MR) imaging techniques may struggle to accurately discriminate these plaque components.
Purpose of the Study:
- To evaluate the utility of quantitative susceptibility mapping (QSM) for characterizing carotid plaque components.
- To compare QSM's performance against conventional vessel wall MR imaging sequences.
Main Methods:
- Seven patients undergoing carotid endarterectomy were scanned using 3T MRI, acquiring magnitude and phase images.
- Quantitative susceptibility mapping (QSM) was calculated from phase images.
- Pathological findings were correlated with QSM susceptibility values and contrast-noise ratios (CNR) from conventional sequences (T1WI, T2WI, PDWI, TOF).
Main Results:
- QSM demonstrated higher relative susceptibility values for hemorrhage compared to lipid-rich necrosis (P = 0.0313).
- Calcification showed significantly lower susceptibility values than lipid-rich necrosis (P = 0.0156).
- Conventional sequences showed no significant difference in CNR between hemorrhage and lipid-rich necrosis, but significant differences for lipid-rich necrosis versus calcification.
Conclusions:
- Quantitative susceptibility mapping (QSM) offers a novel quantitative MRI contrast for reliable differentiation of intraplaque hemorrhage, lipid-rich necrosis, and calcification.
- QSM shows promise in identifying vulnerable carotid plaques, potentially improving risk stratification.
Keywords:
intraplaque hemorrhagemagnetic resonance imagingplaque imagingquantitative susceptibility mappingMore Related Videos
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