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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
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Appendicitis

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Actinomyces in Crohn's-like appendicitis.

Bela A Horvath1, Elena Maryamchik2, Gregory C Miller3,4

  • 1Eastern Connecticut Pathology Consultants, Manchester, CT, USA.

Histopathology
|June 4, 2019
PubMed
Summary
This summary is machine-generated.

Actinomyces infection can cause appendicitis with Crohn's-like features, mimicking Crohn's disease. This study found no Crohn's disease development in patients with Actinomyces-associated appendicitis during follow-up.

Keywords:
ActinomycesCrohn’s diseaseappendicitisappendixgranuloma

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Area of Science:

  • Gastroenterology
  • Pathology
  • Infectious Diseases

Background:

  • Appendicitis with Crohn's-like histology often suggests Crohn's disease or Yersinia infection.
  • Actinomyces infection is a known cause of chronic appendicitis that can histologically resemble Crohn's disease.

Purpose of the Study:

  • To investigate Actinomyces as a cause of appendicitis with Crohn's-like histological features.
  • To differentiate Actinomyces-associated appendicitis from Crohn's disease.

Main Methods:

  • Retrospective analysis of 20 cases of appendicitis with Crohn's-like histological features.
  • Review of patient presentations, imaging studies, and histological findings.
  • Follow-up assessment for development of Crohn's disease.

Main Results:

  • Actinomyces was identified as the cause in 20 cases of appendicitis with Crohn's-like features.
  • Most patients presented with abdominal pain; imaging suggested a mass in five cases.
  • Histological findings included fibrosis and granulomas in seven cases; no patients developed Crohn's disease during a median 37-month follow-up.

Conclusions:

  • Actinomyces can present as Crohn's-like appendicitis, characterized by fibrosis, transmural inflammation, lymphoid hyperplasia, and granulomas.
  • Histological features of Actinomyces appendicitis can mimic Crohn's disease.
  • Actinomyces infection is a distinct entity from Crohn's disease in these cases.