Related Experiment Video

Updated: Jan 24, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
08:40

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library

Published on: April 6, 2012

18.0K

Enhanced Inhibition of Tumorigenesis Using Combinations of miRNA-Targeted Therapeutics

Svetlana Miroshnichenko1, Olga Patutina1

  • 1Laboratory of Nucleic Acids Biochemistry, Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia.

Frontiers in Pharmacology
|June 4, 2019
PubMed

Insights

Modulating microRNAs (miRNAs) offers promising cancer therapy strategies. Combining miRNA-based agents with chemotherapy significantly enhances anticancer efficacy through synergistic effects, improving tumor inhibition.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Tumorigenesis inhibition is a critical scientific challenge.
  • MicroRNAs (miRNAs) are key regulators of cell signaling pathways implicated in cancer.
  • Deregulation of miRNA expression is common in pathological states.

Purpose of the Study:

  • To review strategies for modulating miRNA activity for cancer therapy.
  • To evaluate the impact of miRNA-based therapeutics on tumorigenesis.
  • To assess the efficacy of combined miRNA-based agents and chemotherapy.

Main Methods:

  • Antisense oligonucleotide construction (e.g., miRNA sponges, masks, mimics).
  • MiRNA-targeted artificial ribonucleases (miRNases).
  • Combination therapies involving various miRNA agents and chemotherapeutic drugs.

Main Results:

  • MiRNA modulation strategies include small RNA zippers, miRNases, sponges, masks, anti-miRNA oligonucleotides, and synthetic miRNA mimics.
  • Combined application of miRNA-based agents and chemotherapy shows increased anticancer efficacy.
  • Synergistic effects observed with drug combinations, such as miRNA sponges and cytostatic drugs.

Conclusions:

  • MiRNA-based therapeutics represent a promising avenue for cancer treatment.
  • Combined therapeutic strategies targeting multiple cellular processes involved in tumorigenesis are highly effective.
  • Simultaneous application of distinct miRNA-targeting strategies enhances anticancer therapy outcomes.
Keywords:
antisense oligonucleotidecancerchemotherapygemcitabinemiRNA mimiconcogenic miRNAtemozolomide

More Related Videos

Targeting Olfactory Bulb Neurons Using Combined In Vivo Electroporation and Gal4-Based Enhancer Trap Zebrafish Lines08:18

Targeting Olfactory Bulb Neurons Using Combined In Vivo Electroporation and Gal4-Based Enhancer Trap Zebrafish Lines

Published on: August 15, 2011

12.6K
Enhanced Oil Recovery using a Combination of Biosurfactants13:19

Enhanced Oil Recovery using a Combination of Biosurfactants

Published on: June 3, 2022

5.9K

Related Concept Videos

Feedback Inhibition00:46

Feedback Inhibition

Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
56.9K
Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
91.7K
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.7K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.8K
Therapeutic Communication01:30

Therapeutic Communication

Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
7.7K